Breast Cancer Breakthroughs: ESMO 2025 Highlights

Experts in Dana-Farber’s Breast Oncology Center discuss highlights in breast cancer research innovation presented at ESMO25 in Berlin, Germany, including what the data mean, how it can be used in clinic, and what’s next in the field of breast cancer research.


ESMO25 Breast Cancer Highlights

Harold Burstein, MD, PhD, and other breast cancer experts at Dana-Farber discuss important breast cancer research presented at ESMO 2025.
Harold Burstein, MD, PhD

Harold Burstein, MD, PhD

Medical Oncology

ESMO25 Breast Cancer Highlights: evERA and SERENA6

Harold Burstein, MD, PhD, and Erica Mayer, MD, MPH, discuss the evERA and SERENA6 trials investigating oral selective estrogen receptor degraders (SERDs).
Erica Mayer, MD, MPH

Erica Mayer, MD, MPH

Medical Oncology

ESMO25 Breast Cancer Highlights: DESTINY-Breast11 & DESTINY-Breast05

Harold Burstein, MD, PhD, and Guilherme Nader Marta, MD, discuss the DESTINY-Breast11 and DESTINY-Breast05 trials examining trastuzumab deruxtecan in HER2-positive breast cancer.

ESMO25 Breast Cancer Highlights: Antibody-Drug Conjugates

Harold Burstein, MD, PhD, and Ilana Schlam, MD, MPH, discuss OptiTROP-Breast02 and other trials investigating antibody-drug conjugates (ADCs).

ESMO25 Breast Cancer Highlights: ASCENT-03 and TROPION-Breast02

Harold Burstein, MD, PhD, and Ana Garrido- Castro, MD, discuss the ASCENT-03 and TROPION-Breast02 trials, investigating antibody-drug conjugates for triple-negative breast cancer.
Ana C. Garrido-Castro, MD

Ana C. Garrido-Castro, MD

Medical Oncology

ESMO25 Breast Cancer Highlights: monarchE and NATALEE

Harold Burstein, MD, PhD, and Sarah Sammons, MD, discuss the monarchE and NATALEE trials, investigating CDK4/6 inhibitors for high-risk, early stage, HR+ breast cancer.

ESMO25 Breast Cancer Highlight Recap

Harold Burstein, MD, PhD, summarizes important breakthroughs presented at ESMO 2025 for all sub-types and stages of breast cancer.
Harold Burstein, MD, PhD

Harold Burstein, MD, PhD

Medical Oncology

ASCENT-03 Study Presented by Sara Tolaney, MD, MPH

Dr. Sara Tolaney details research in The New England Journal of Medicine showing the ADC sacituzumab govitecan improved outcomes for patients with advanced triple-negative #BreastCancer ineligible for immune checkpoint inhibitors.
Sara Tolaney, MD, MPH

Sara Tolaney, MD, MPH

Medical Oncology

Paolo Tarantino, MD, PhD, on ADCs

The Next Frontier of Antibody-Drug Conjugate Development - Dana-Farber's Paolo Tarantino, MD, discussed how to optimize the safety of antibody drug conjugates at a session during ESMO25.